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    Mahape
    Drugs Discovery
  • Drugs Discovery

    Overview
    New Chemical Entity (NCE)
    New Biologics Entity (NBE)
    Research Pipeline
    R&D Centre of Excellence
    Overview
    Mahape
    Switzerland
    Oxford
    Sinnar
    Scientific Advisory Board
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    Oxford
  • New Chemical Entity (NCE) R&D Facility – Navi Mumbai, India

     

    Glenmark’s R&D centre at Mahape was established in the year 2000, as Glenmark’s first step into NCE discovery, and has led the way for the company in its R&D efforts since then

    This state of the art R&D centre is spread over 1,25,000 sq feet with over 200 scientists working on multiple target in broad therapeutic areas of inflammation, inflammatory pain and metabolic disorders

    It is a complete end to end setup with expertise in all areas of NCE discovery and development ranging from target selection to clinical development

     

    Capabilities

     

    The research facility is equipped with the most modern infrastructure required to carry out activities such as:

    Medicinal Chemistry: Availability of several focused libraries generated in-house over the last eight years

    Process chemistry: Lab scale reactors for synthesis of complex and novel chemical structures with scale-up capability to meet pre-IND requirements

    Analytical: Fully equipped with state of the art analytical equipment including HPLCs, GCs, NMR, XRD etc.

    In–vitro Biology: Complete set-up for in-vitro assay development including microbial and mammalian cell cultures, molecular biology, radiometric and biochemical assays

    In–vivo pharmacology: In-house set up for a wide range of animal models in the area of inflammation, inflammatory pain and metabolic disorders

    Project Management: Sophisticated project management tools in place for coordination and smooth running of cross-functional projects

    Library: Access to global databases and scientific literature through physical and online subscriptions

     

    People

     

    Skilled and highly experienced researchers :

    Highly experienced team with proven delivery capabilities as illustrated by Glenmark’s strong in-house pipeline of compounds in Inflammation, Pain and Metabolic Disorders.

    Leverages India’s strong skills in chemistry for medicinal chemistry and process chemistry work. One of the most reputed medicinal chemistry teams in India with senior leadership team being around nearly since the inception of this R&D Facility.

    Complimented by excellent Biology capabilities developed over the years through a combination of in-house training as well as attracting highly qualified people with strong international experience in both industry and academia

    Clinical development team with Medical doctors having strong background in designing and conducting clinical trials in India. Global leadership in clinical development provided by Glenmark’s clinical development centre in Oxford.

    Overall 20% Scientists have Ph.D.´s and 10 Scientists have international Post-docs.


    Intellectual Property support in India & the US

     

    Molecules in Pipeline

     

    The R&D centre has been responsible for discovering 13 NCEs in a short span of nine years. Of these, six molecules have reached clinical trials, making Glenmark the leader in the Drug Discovery arena.

  • SCRIP Award